{"id":83144,"date":"2026-02-25T09:09:54","date_gmt":"2026-02-25T13:09:54","guid":{"rendered":"https:\/\/conati-cal.mincyt.gob.ve\/?page_id=83144"},"modified":"2026-02-25T09:15:37","modified_gmt":"2026-02-25T13:15:37","slug":"alphagenome-avance-revolucionario-o-dilema-etico-en-el-estudio-del-genoma-humano","status":"publish","type":"page","link":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/alphagenome-avance-revolucionario-o-dilema-etico-en-el-estudio-del-genoma-humano\/","title":{"rendered":"AlphaGenome: \u00bfAvance revolucionario o dilema \u00e9tico en el estudio del genoma humano?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"83144\" class=\"elementor elementor-83144\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1797feed elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"1797feed\" 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data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/conati-cal.mincyt.gob.ve\/wp-content\/uploads\/4922506217910284032_119.jpg\" title=\"-4922506217910284032_119\" alt=\"-4922506217910284032_119\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-56285760\" data-id=\"56285760\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-72da4a9c elementor-flip-box--effect-fade elementor-widget elementor-widget-flip-box\" data-id=\"72da4a9c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation_mobile&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-flip-box\" tabindex=\"0\">\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__front\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper elementor-view-default\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-flip-box__layer__title\">\n\t\t\t\t\t\t\t\tNOTICIAS\t\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__back\">\n\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t<div 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elementor-top-column elementor-element elementor-element-14509e90\" data-id=\"14509e90\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-293bd4f0 elementor-flip-box--effect-fade animated-slow elementor-invisible elementor-widget elementor-widget-flip-box\" data-id=\"293bd4f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-flip-box\" tabindex=\"0\">\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__front\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper elementor-view-default\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\t\tNOTICIAS\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"elementor-flip-box__layer elementor-flip-box__back\">\n\t\t\t<div class=\"elementor-flip-box__layer__overlay\">\n\t\t\t\t<div class=\"elementor-flip-box__layer__inner\">\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-flip-box__layer__description\">\n\t\t\t\t\t\t\tNOTICIAS\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<header class=\"elementor-section elementor-top-section elementor-element elementor-element-6a38d1e elementor-section-content-middle elementor-section-boxed 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data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4a8d29ae\" data-id=\"4a8d29ae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a8fa862 elementor-widget elementor-widget-image\" data-id=\"7a8fa862\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/conati-cal.mincyt.gob.ve\/wp-content\/uploads\/IMG_20260224_154633_433-1080x720-1-1024x683.jpg\" class=\"attachment-large size-large wp-image-83146\" alt=\"\" srcset=\"https:\/\/conati-cal.mincyt.gob.ve\/wp-content\/uploads\/IMG_20260224_154633_433-1080x720-1-1024x683.jpg 1024w, https:\/\/conati-cal.mincyt.gob.ve\/wp-content\/uploads\/IMG_20260224_154633_433-1080x720-1-300x200.jpg 300w, https:\/\/conati-cal.mincyt.gob.ve\/wp-content\/uploads\/IMG_20260224_154633_433-1080x720-1-768x512.jpg 768w, https:\/\/conati-cal.mincyt.gob.ve\/wp-content\/uploads\/IMG_20260224_154633_433-1080x720-1.jpg 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-40be988a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"40be988a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c0ef87e\" data-id=\"1c0ef87e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-77e94d95 elementor-widget elementor-widget-heading\" data-id=\"77e94d95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">AlphaGenome: \u00bfAvance revolucionario o dilema \u00e9tico en el estudio del genoma humano?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-26f64887 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26f64887\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5a8f7400\" data-id=\"5a8f7400\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5df905fe elementor-widget elementor-widget-text-editor\" data-id=\"5df905fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Recientemente, la empresa Google dio a conocer su herramienta de Inteligencia Artificial, llamada AlphaGenome, la cual permitir\u00e1 avanzar hacia la comprensi\u00f3n del genoma. Esto, debido a que esta herramienta puede analizar c\u00f3mo determinadas porciones del ADN regulan la actividad de los genes en la c\u00e9lula.<\/p><p>De acuerdo con la revista Nature, los modelos de aprendizaje profundo que predicen mediciones gen\u00f3micas funcionales a partir de secuencias de ADN son esenciales para entender el c\u00f3digo regulador gen\u00e9tico. Sin embargo, los m\u00e9todos actuales enfrentan un desaf\u00edo en equilibrar la longitud de la secuencia de entrada con la resoluci\u00f3n de la predicci\u00f3n, lo que limita su eficacia.<\/p><p>Seg\u00fan su creador, citado por la revista cient\u00edfica, se cre\u00f3 AlphaGenome, un modelo unificado que procesa 1 Mb de secuencia de ADN y puede predecir miles de pistas gen\u00f3micas funcionales con una resoluci\u00f3n de un solo par de bases en m\u00faltiples modalidades, incluyendo expresi\u00f3n g\u00e9nica, inicio de transcripci\u00f3n, accesibilidad de la cromatina, modificaciones de histonas, uni\u00f3n de factores de transcripci\u00f3n, y m\u00e1s.<\/p><p>AlphaGenome fue entrenada con genomas humanos y de rat\u00f3n, logrando igualar o superar a los modelos m\u00e1s avanzados en 25 de 26 evaluaciones de predicci\u00f3n del efecto de variantes.<\/p><p>Su capacidad para evaluar simult\u00e1neamente los efectos de variantes en diversas modalidades permite una representaci\u00f3n precisa de los mecanismos de variantes cl\u00ednicamente relevantes. El impacto de la variaci\u00f3n en la secuencia del genoma representa un desaf\u00edo biol\u00f3gico, especialmente en el caso de las variantes no codificantes, que se encuentran fuera de las regiones que codifican prote\u00ednas.<\/p><p>Estas variantes son complejas de interpretar debido a sus m\u00faltiples consecuencias moleculares, como la modulaci\u00f3n de la accesibilidad de la cromatina, las modificaciones epigen\u00e9ticas y la conformaci\u00f3n tridimensional del genoma.<\/p><p>Adem\u00e1s, pueden afectar la disponibilidad del ARN mensajero al alterar la expresi\u00f3n g\u00e9nica o modificar el empalme de las secuencias.<\/p><p>El verdadero desaf\u00edo, en la actualidad, va m\u00e1s all\u00e1 de descifrar el genoma con algoritmos cada vez m\u00e1s complejos, es contar con principios \u00e9ticos que apunten hacia la protecci\u00f3n de la humanidad.<\/p><p>En Venezuela no rechazamos los avances de la tecnolog\u00eda, pero creemos necesarios que exista un marco \u00e9tico, soberano y orientado al bien com\u00fan.<\/p><p>No podemos permitir que el ser humano sea tratado como un simple conjunto de datos para alimentar modelos de empresas privadas.<\/p><p>Actualmente, avanzamos con un proyecto de Ley de Inteligencia Artificial en discusi\u00f3n en la Asamblea Nacional, adem\u00e1s del reci\u00e9n presentado C\u00f3digo de \u00c9tica para la Implementaci\u00f3n de la IA, que busca asegurar que las tecnolog\u00edas emergentes se desarrollen alineadas con principios como soberan\u00eda, transparencia y protecci\u00f3n de datos.<\/p><p>Venezuela, adem\u00e1s, desempe\u00f1\u00f3 un papel crucial en la creaci\u00f3n del primer marco \u00e9tico global para la neurotecnolog\u00eda, el cual fue adoptado por la UNESCO en noviembre de 2025.<\/p><p>Abogamos por una ciencia humanista, enfoc\u00e1ndose en la regulaci\u00f3n del uso de tecnolog\u00edas que afectan el cerebro humano. Este enfoque resalta la importancia de la \u00e9tica en el desarrollo de la neurociencia, con el objetivo de proteger la dignidad y la privacidad mental de las personas frente a posibles manipulaciones.<\/p><p>Solo con una base \u00e9tica s\u00f3lida puede garantizarse una verdadera innovaci\u00f3n que beneficie a todos sin comprometer los valores fundamentales.<\/p><p><strong>Por Gabriela Jim\u00e9nez Ram\u00edrez<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3de5becd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3de5becd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element 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center;\">Av. Universidad. Torre Ministerial. Piso 14. La Hoyada, Caracas.<\/p><p style=\"text-align: center;\">Telefonos: (0212) 535 89 55 Ext. 9202<\/p><p style=\"text-align: center;\">CONATI | RIF: G-200113863<\/p><p style=\"text-align: center;\">CONATI. \u00a9 2021 Copyright. Todos los Derechos Reservados.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>NOTICIAS NOTICIAS NOTICIAS NOTICIAS AlphaGenome: \u00bfAvance revolucionario o dilema \u00e9tico en el estudio del genoma humano? Recientemente, la empresa Google dio a conocer su herramienta de Inteligencia Artificial, llamada AlphaGenome, la cual permitir\u00e1 avanzar hacia la comprensi\u00f3n del genoma. Esto, debido a que esta herramienta puede analizar c\u00f3mo determinadas porciones del ADN regulan la actividad [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":83146,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-83144","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/pages\/83144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/comments?post=83144"}],"version-history":[{"count":4,"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/pages\/83144\/revisions"}],"predecessor-version":[{"id":83149,"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/pages\/83144\/revisions\/83149"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/media\/83146"}],"wp:attachment":[{"href":"https:\/\/conati-cal.mincyt.gob.ve\/index.php\/wp-json\/wp\/v2\/media?parent=83144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}